WHO Drug Dictionary

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Dr.DavidWllker,United States,Professional
Published Date:11-07-2017
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WHO Drug Dictionary Magnus Wallberg Dar Es Salaam, Tanzania th, November 24 2009 magnus.wallbergwho-umc.orgGeneral information • The WHO Drug Dictionary contains data from 1968 onwards • The content today is originating mostly from IMS and National Drug names References • No entries are deleted even though they are withdrawn from the market, since old case reports might be coded with these products. – They are marked as OLD FORM Magnus Wallberg, UMCDrug/Medicinal Product Classification • Structure – to allow easy and flexible data retrieval –and analysis • Classifications – Chemical – Indication • Hierarchical – to allow different levels of precision – to facilitate navigation and aggregation • Up to date Magnus Wallberg, UMCThe WHO Drug Dictionary (WHO-DD) • A database with information about medicinal products from all over the world – it contains medicinal products and information related to them in a relational database system • Information is provided in a consistent and structured way • It provides useful groupings of data – useful for both data input and output • It is continuously updated Magnus Wallberg, UMCThe WHO-DD • A source of international drug names • Substance names according to International Non Proprietary Names (INN) • Drugs classified according to the Anatomical- Therapeutic-Chemical (ATC) classifications system • Information on companies and reference sources Magnus Wallberg, UMCMedicinal product names • Proprietary names – single-ingredient – multiple-ingredient • Nonproprietary/Generic names – single-ingredient – multiple-ingredient Magnus Wallberg, UMCPreferred name • Single ingredient drugs – Nonproprietary names • Multiple ingredient drugs – Trade names • First reported brand of a given ingredient combination – Nonproprietary names Magnus Wallberg, UMCTypes of medicinal products in WHO-DD • The majority of the entries refer to conventional (chemical substance) medicinal products but the WHO-DD also includes – herbal remedies –vaccine – blood products – homeopatic remedy – dietary supplement Magnus Wallberg, UMCCodes and IDs • Link products with the same ingredients – generics – brands Particularly important for international exchange of information, since there are different product names in different countries • Link products containing the same base ingredient, but different salt/esters Magnus Wallberg, UMCCodes and IDs • Drug Code identifies –Ingredient(s) •Salts/Esters –Names Aspirin – 000027 01 004 Magnecyl – 000027 01 006 • Medicinal Product ID identifies a unique entry – a numeric name. Magnus Wallberg, UMCHow do we use WHO-DD • Those who report ICSRs to the UMC need to give the product name and when needed the National product name compendia • The reported medicinal product is linked to the WHO-DD which contains more information on the product ICSR WHO-DD Patient data Reaction data VigiBase Vioxx 5 mg tablet WHO-DD Merck, Sweden Medication data ICSR ATC code: M01AH database Vioxx 5 mg d Ingr.: rofecoxib More data... Magnus Wallberg, UMCWith the WHO-DD linked to ICSRs we can –Sort –Group – Search ICSRs according to: – product name –ingredients – therapeutic group etc. Magnus Wallberg, UMCAn example Ingredient Salt/Ester Brand name Medicinal /Base product Paracetamol - Alvedon 500 mg Tablets 1 2 Paracetamol - Alvedon Fluid 3 Paracetamol - Acetamol Tablets 4 Paracetamol Paracetamol Acetasod Intravenous sodium Paracetamol Paracetamol Acecloride Unspecified hydrocloride 1 – Search on medicinal product level 2 – Search on brand name level 3 – Search on Salt/Ester level 4 – Search on base ingredient level Magnus Wallberg, UMC ATC in WHO Drug Dictionary ATC Classification Index issued by the WHO Collaborating Centre, Oslo, Norway Magnus Wallberg, UMCATC in WHO Drug Dictionary • Help for drug utilisation research • Hierarchical classification useful for navigation and aggregation • Applicable to both single and multiple ingredient drugs • Medicinal products are classified according to the main therapeutic use • Revised yearly Magnus Wallberg, UMCATC in WHO Drug Dictionary N05BA - Benzodiazepine derivatives Medicine Chemical drug Anatomical level CNS drug Therapeutic level Sedative ATC Benzodiazepine Chemical level Diazepam Generic level (ingredient/s) Report entry Valium Proprietary name level Valium tablet Valium 10mg tablet Magnus Wallberg, UMCATC Classification Main Groups Screen shot from DD Browser Magnus Wallberg, UMCScreen shot from DD Browser Magnus Wallberg, UMCAn example Ingredient Salt/Ester Brand name Medicinal /Base product Paracetamol - Alvedon 500 mg Tablets 1 2 Paracetamol - Alvedon Fluid 3 Paracetamol - Acetamol Tablets 4 Paracetamol Paracetamol Acetasod Intravenous sodium Paracetamol Paracetamol Acecloride Unspecified hydrocloride 1 – Search on medicinal product level 2 – Search on brand name level 3 – Search on Salt/Ester level 4 – Search on base ingredient level Magnus Wallberg, UMCAn example Ingredient Salt/Ester Brand name Medicinal /Base product Paracetamol - Alvedon 500 mg Tablets Paracetamol - Alvedon Fluid Paracetamol - Acetamol Tablets Paracetamol Paracetamol Acetasod Intravenous sodium Paracetamol Paracetamol Acecloride Unspecified hydrocloride Acetylsalicylic - Aspirin Tablets acid Magnus Wallberg, UMC